HARM REDUCTION · CATALOG
Ancillaries.
The drugs and supplements biohackers and bodybuilders discuss for harm reduction, grouped by category — chosen from what matters most in harm-reduction conversations. One line per entry on what it does. Nothing more.
Educational content only. Not medical advice. Nothing here is a recommendation, a dose, a protocol, or a source. Prescription drugs listed here are prescription-only and clinician-managed — never self-prescription guidance. If anything here applies to you, talk to a clinician before acting on it. For the full disclaimer, see the disclaimer.
Heart & blood pressure
| Entry | What it does | Evidence |
|---|---|---|
| Telmisartan | Angiotensin receptor blocker (ARB) that lowers blood pressure. | Strong |
| Nebivolol | Beta blocker that lowers blood pressure and heart rate. | Strong |
| Tadalafil | PDE5 inhibitor that widens blood vessels. | Strong |
| Finerenone | Mineralocorticoid receptor antagonist studied for kidney and heart protection. | Strong |
| ACE inhibitors (class) | Block the angiotensin-converting enzyme, lowering blood pressure. | Strong |
| Statins (class) | Lower LDL cholesterol. | Strong |
Estrogen & prolactin control
| Entry | What it does | Evidence |
|---|---|---|
| Exemestane (aromasin) | Aromatase inhibitor that reduces estrogen formation. | Strong |
| Aromatase inhibitors (class) | Reduce estrogen formation by blocking aromatase. | Strong |
| SERMs, e.g. tamoxifen / raloxifene (class) | Block estrogen receptors in selected tissues. | Strong |
| Dopamine agonists, e.g. cabergoline (class) | Lower prolactin by mimicking dopamine at its receptors. | Strong |
Liver & kidney support
| Entry | What it does | Evidence |
|---|---|---|
| NAC (N-acetylcysteine) | Glutathione precursor with antioxidant activity. | Weaker |
| TUDCA | Bile acid studied for liver and bile support. | Weaker |
Sleep support
| Entry | What it does | Evidence |
|---|---|---|
| Doxepin | Sedating antidepressant used for sleep maintenance. | Strong |
| Trazodone | Sedating antidepressant used for sleep onset. | Strong |
| Melatonin | Circadian timing signal, not a sedative. | Strong |
| Diphenhydramine | Antihistamine with sedating effects. | Strong |
Metabolic & general
| Entry | What it does | Evidence |
|---|---|---|
| SGLT2 inhibitors, e.g. empagliflozin / dapagliflozin (class) | Increase glucose excretion through the urine, with kidney and heart outcome data. | Strong |
| Fish oil | Omega-3 supplement discussed for lipid support. | Weaker |
Deliberately not on this page
Thyroid replacement is medical treatment, not an ancillary, so it does not belong in this catalog. Primary compounds are Archive territory, not ancillaries, and live in the compound records instead. Keeping those lines clean is what keeps this page a harm-reduction catalog rather than a medicine cabinet.
Related: Harm Reduction for the principles and topic pages, Learn for physiology and lab foundations, the Archive for individual compound records. Educational content only. Not medical advice.